New York, NY., Nov.23, 2010 – Canaan Data Service Group, the leading service provider in data recovery/restoration industry, has announced that the Nobel laureate Sir Paul Nurse with his secretary, Ms. Ryoko Mandeville, visited the New York City facility of Canaan. The president of Canaan, Mr. Sam Peng, had a special meeting with Dr.Nurse for about 1 hours and 30 minutes, during the meeting Mr. Sam Peng presented the digitally restored video files to Dr.Paul Nurse. Dr.Paul Nurse highly praised Canaan’s wonderful work on his project.
Sir.Paul Nurse (left) and Mr.Sam Peng (Right)
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About Dr. Paul Nurse, President & Professor
Laboratory of Yeast Genetics and Cell Biology
Dr. Nurse’s research focuses on the molecular machineries that control cell division and cell shape. Using the fission yeast Schizosaccharomyces pombe as a model system, his laboratory studies the cell cycle and cell morphogenesis controls operative in eukaryotic cells. His major past contribution was the codiscovery of cyclin-dependent kinase (CDK) as the key regulator molecule controlling S phase and mitosis, findings that have had implications for understanding cell reproduction, cell growth, development and cancer.
Present work in the Nurse laboratory is in three areas: the cell cycle, cell form and genomic studies. Research on the cell cycle has included controls acting over S phase. The Nurse lab has mapped all the replication origins in fission yeast and has found that they are used similarly during both the mitotic and meiotic S phases, although with differing efficiencies. Origin efficiency varies greatly with more efficient origins generally being initiated early in S phase. The ORC proteins, which form a landing pad for other DNA replication proteins at origins, bind the efficient origins early in the cell cycle, and as a consequence these origins compete more effectively for other later-associating DNA replication proteins. This provides an explanation for the temporal order of origin firing during S phase. When DNA replication stalls, the subsequent mitosis is blocked because the DNA replication initiation factor Cdc18 (Cdc6 in other organisms) forms a complex on chromosomes together with checkpoint protein kinases. These then signal to the cell that mitosis should not take place. A cell geometry sensing mechanism that can monitor cell size has been revealed based on a Pom1 gradient along the length of the cell. This mechanism regulates CDK activation at the onset of mitosis.
Dr. Nurse’s recent work on cell form has shown that microtubules making up the cell’s cytoskeleton become organized along the long axis of the cell by kinesin motor mediated microtubular sliding. This long axis organization can occur without microtubular organizing centers, showing that the microtubules self-organize de novo along the length of the cell. A key problem in cell biology is what determines the size and shape of membrane-bounded organelles. The nucleus in a fission yeast cell varies in size proportionally to the size of the cell. In contrast, DNA content has no effect on nuclear size, suggesting that there is a control mechanism that maintains nuclear size in direct relation to cellular size.
Recent genomic studies have generated a resource whereby every gene in the fission yeast genome has been individually deleted. The Nurse lab is using this resource to characterize all the genes necessary for cell viability and for various cell functions including progression through the cell cycle, generation of cell form, cell size and nuclear shape and size.
Dr. Nurse, a native of the United Kingdom, graduated from Birmingham University in 1970 and received his Ph.D. in cell biology and biochemistry from the University of East Anglia in 1973. He did postdoctoral work at universities in Bern, Switzerland, Edinburgh, and Sussex, and joined the Imperial Cancer Research Fund (ICRF) in London in 1984. In 1988 he moved to the University of Oxford as chair of its department of microbiology, and he returned to ICRF in 1993 as director of research. He became director general in 1996 and in 2002 was appointed chief executive of Cancer Research UK, formed when ICRF merged with the Cancer Research Campaign. He moved his laboratory to the United States upon being named president of Rockefeller University in 2003. He is also director of the Anderson Center for Cancer Research at Rockefeller.
Dr. Nurse is a member of The Royal Society and a foreign associate of the U.S. National Academy of Sciences. He received The Royal Society’s Royal and Copley Medals and the Legion of Honor in 2002 and the Nobel Prize in Physiology or Medicine in 2001. In 1999 he was honored with knighthood in Great Britain for services in cancer research and cell biology and since 2000 has been a member of CST advising the UK Prime Minister on science and technology.
About Canaan Data Service Group.
Canaan Data Service Group provides technology-driven services and tools to help business and government entities as well as consumers restore, diagnose, produce and present data efficiently and cost-effectively. By uisng its own software, Canaan Data Service Group provides the following services: file data recovery, disk data recovery, computer data recovery, windows data recovery, cd data recovery, card data recovery, flash data recovery, forensic data recovery, ntfs data recovery, backup data recovery , computer recovery, computer file recovery, forensic computer recovery, computer hard drive recovery, hard disk crash recovery, disaster recovery, restore backup, backup recovery, data disaster recovery, backup disaster recovery, computer disaster recovery, disaster recovery services, diskette recovery, diskette data recovery, disk recovery, windows disk recovery, xp disk recovery, disks recovery, floppy disk recovery, boot disk recovery, memory recovery, memory card recovery, memory data recovery, memory card data recovery, flash memory recovery, sd memory recovery, sd card memory recovery, flash memory data recovery, memory card file recovery, laptop recovery, toshiba laptop recovery, laptop hard drive recovery, laptop hard disk recovery, paper and electronic discovery, jury consulting, ESI consulting, and presentation services. Canaan Data Service Group is a technology services division of Canaan Technologies. For more information about Canaan Technologies and its offerings please visit www.CanaanTechs.com; www.CanaanMedia.com